文章信息/Info

Title:

Polymers in 3D Bioprinting: Progress and Challenges

作者:

毛宏理; 顧忠偉

南京工業(yè)大學(xué) 材料科學(xué)與工程學(xué)院

Author(s):

MAO Hongli;  GU Zhongwei

College of Materials Science and Engineering, Nanjing Tech University

關(guān)鍵詞:

生物3D打印; 生物材料; 合成高分子; 天然高分子; 脫細胞外基質(zhì)

Keywords:

3D bioprinting;  biomaterials;  synthetic polymer;  natural polymer;  decellularizate ECM

DOI:

10.7502/j.issn.1674-3962.2018.12.02

文獻標志碼:

A

摘要:

生物3D打印作為3D打印的一個重要分支，在健康醫(yī)療領(lǐng)域表現(xiàn)出巨大的應(yīng)用價值。材料則是目前該領(lǐng)域的研究熱點，更是關(guān)乎其深入發(fā)展和實際應(yīng)用的關(guān)鍵因素。其中，高分子材料在生物3D打印，尤其是載細胞打印中，可謂異軍突起，成為發(fā)展最快的一類打印材料。鑒于此，本文在簡要介紹生物3D打印技術(shù)及相關(guān)原理的基礎(chǔ)上，對生物3D打印在健康醫(yī)療領(lǐng)域的應(yīng)用進行了分類敘述。同時，綜述了生物3D打印對材料的特性要求，并重點針對生物3D打印高分子材料，詳細介紹了典型合成高分子及天然高分子在生物3D打印中的最新研究進展。最后對高分子材料在生物3D打印中未來發(fā)展趨勢和研究方向提出展望。

Abstract:

As an important branch of 3D printing, 3D bioprinting showed great petential in the field of health care. Printing materials are currently the research hotspots in this field, and they are also the key factors for the further development and application of 3D bioprinting. Materials currently used in the field of 3D bioprinting are predominantly based on either synthetic molecules or naturally derived polymers. In view of this, this paper introduced the technology and principles in 3D bioprinting firstly, and then described the application of 3D bioprinting in the field of health care. Meanwhile, the requirements on bioprinting materials were reviewed, and the recent progress of typical synthetic polymers and natural polymers used in 3D bioprinting was introduced in detail. Finally, the future development trend and research direction of polymer materials in 3D bioprinting were proposed.