文章信息/Info

Title:

Research Progress of Nanomaterials Based on Antioxidant Function in Radiation Protection

文章編號:

1674-3962(2026)01-0037-12

作者:

何明玥; 昌依凌; 易曼; 高妙; 歐舒斐; 李基根

中國人民解放軍火箭軍廣州特勤療養(yǎng)中心 醫(yī)學影像科，廣東 廣州 510000

Author(s):

HE Mingyue;  CHANG Yiling;  YI Man;  GAO Miao;  OU Shufei;  LI Jigen

Department of Medical imaging, Guangzhou Special Service Recuperation Center of PLA Rocket Force,Guangzhou 510000, China

關(guān)鍵詞:

輻射防護; 放射治療; 抗氧化; 類酶活性; 納米酶

Keywords:

adiation protection;  radiotherapy;  anti-oxidation;  enzyme-like activity;  nano-enzyme

分類號:

TB34；R318.08

DOI:

10.7502/j.issn.1674-3962.202411024

文獻標志碼:

A

摘要:

放射治療（簡稱放療）是治療腫瘤性相關(guān)疾病的有效方法。然而，高頻率的放療容易誘發(fā)多種放射性炎性疾病，造成周圍正常組織的損傷。因此，減輕輻射導致的多種副作用對提高放療效果至關(guān)重要。輻射誘導過量活性氧生成，進而蓄積于組織器官內(nèi)形成炎性環(huán)境，引發(fā)細胞凋亡，導致多種組織器官損傷。清除自由基以抵抗人體器官過度氧化是現(xiàn)有電離輻射防護手段的主流途徑。然而，傳統(tǒng)的電離輻射防護劑因穩(wěn)定性差、副作用多、制作成本高及體內(nèi)循環(huán)過快等缺陷，制約了其輻射防護功能的發(fā)展。為此，研究者們開發(fā)了大量具有納米酶功能的生物材料用于解決放療副作用，其中納米材料的類酶活性開辟了輻射防護新途徑，提升了輻射防護劑的穩(wěn)定性及可持續(xù)生物活性�？偨Y(jié)了近年來具有抗氧化功能的納米材料在不同組織器官中輻射防護的最新進展，旨在為預防放療副作用及治療放療誘導的相關(guān)疾病提供新的思路。此外，進一步討論了現(xiàn)有納米材料在輻射防護領域的發(fā)展前景及挑戰(zhàn)。

Abstract:

Radiotherapy is an efficacious method for treating tumor-related diseases. However, high-frequency radiotherapy can readily result in a spectrum of radiation-induced inflammatory conditions, leading to damage to surrounding normal tissues. It is therefore important to reduce the side effects of radiation and improve the radiotherapy effect. Ionizing radiation induces the generation of excessive reactive oxygen species, which accumulate in tissues and organs to form an inflammatory environment, trigger cell apoptosis and lead to a variety of tissue and organ damage. The principal method of radioprotection is the removal of reactive oxygen species in order to resist the excessive oxidation of human organs. However, the traditional radioprotective agent has numerous shortcomings, including instability, a multitude of adverse effects, a high production cost and rapid circulation in the body, which collectively impede the advancement of its radiation protection capabilities. In light of these considerations, researchers have developed a plethora of biomaterials with nano-enzyme functionalities to mitigate the adverse effects of radiotherapy. Among these, the enzyme-like activity of nanomaterials represents a novel avenue for radiation protection, offering enhanced stability and sustained biological activity for radiation protection agents. This paper presents a summary of the recent progress in the development of antioxidation nanomaterials for the purpose of radiation protection in different tissues and organs. The aim of this paper is to provide new ideas for the prevention of radiotherapy side effects and the treatment of radiation�瞚nduced related diseases. In addition, the development prospects and challenges of existing nanomaterials in radiation protection are discussed.