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Title:: The Compatibility in vitro and in vivo of Novel Biomedical Magnesium Alloy

Author(s):: GAO Zhihan1; GAO Mingze2; SUN Yi3; LIU Haifeng1; FU Gaojie4; XIAO Yang4; （1. Medical Research Center, Mudanjiang Medical University, Mudanjiang 157011,China）（2. School of Medical Imaging, Mudanjiang Medical University, Mudanjiang 157011, China）（3. School of Business Administration, Dongbei University of Finance and Economics, Dalian 116000, China）（4. The Second Affiliated Hospital, Mudanjiang Medical University, Mudanjiang 157011, China)

Keywords:: magnesium alloy; gallium; strontium; biocompatibility; biodegradation; orthopedic implants

Abstract:: In recent years, magnesium-based alloys have attracted extensive attention due to their biodegradability and mechanical properties similarity with those of cortical bone. This paper investigated the compatibility in vitro and in vivo of magnesium alloys containing different amounts of gallium and strontium and whether they have the ability of promoting bone healing. The materials of each group were co-cultured with human bone marrow mesenchymal stem cells (hBMSCs) in Duchenne modified eagle medium (DMEM), and the cytotoxicity of the materials in vitro was evaluated by fluorescence staining. The materials were implanted into the femur of rats, and X’ray fluoroscopy and Micro-CT were used to evaluate the compatibility in vivo and effect of the planted materials, SEM was used to observe the changes of the surface morphology of the planted materials. Compared with pure titanium, magnesium alloys have a certain inhibitory effect on cells proliferation. The alloy material containing strontium has better bone forming ability, and the degradation rate is lower than that of pure magnesium.