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Title:: Preliminary Clinical Application Research of Personalized PEEK Mandibular Implant Injected with 3D Printed Resin Mold

Author(s):: LIU Huilong1; TIAN Lei2; SUN Wensen3; QIN Mian3; CHEN Ruomeng4; WU Yan1; WANG Chunyu1; LIU Yanpu2; LIU Yaxiong 5; 1. Medical 3D Printing Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China2. Department of Oral and Maxillofacial Surgery,The Third Hospital of Air Force Military Medical University,Xi‘a(chǎn)n 710032, China3. State Key Laboratory for Manufacturing Systems Engineering,Xi’an Jiaotong University, Xi‘a(chǎn)n 710049, China.et al.

Keywords:: 3D printing; resin mold; polyetheretherketone (PEEK); injection molding; clinical application

Abstract:: In order to promote the clinical application of personalized poly-ether-ether-ketone (PEEK) implant formed by 3D printing technology of stereolithography and injection molding process, the assembly safety between PEEK mandibular implant and bone was evaluated, and then the biocompatibility characterization of PEEK raw material and PEEK injection molded implant material were tested by in vitro cytotoxicity test. Finally, personalized PEEK total temporomandibular joint prostheses were manufactured by using injection molding with 3D printed resin mold, and a patient with severe hemifacial shortness syndrome was successfully treated in combination with digital orthognathic surgery. The results show that, the design thickness of PEEK mandibular implant should not be less than 2 mm; the PEEK raw material used in the process has no toxic effect on cells, and no new toxic substances is introduced in the whole process; one operation realizes the reconstruction of temporomandibular joint, the repair of mandibular defect and the accurate correction of partial jaw deformity; the operation has good effect, operation safety and high patient satisfaction. Therefore, personalized PEEK mandibular implant injected with 3D printed resin mold is an effective method for the treatment of severe hemifacial shortness syndrome, this study lays a foundation for the wider clinic application of personalized PEEK implants.