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Author(s):: JIAO Yanpeng; LI Lihua; LUO Binghong; ZHOU Changren; (Department of Materials Science and Engineering, Jinan University, Guangzhou 510632，China)

摘要:: 材料植入體內(nèi)必然引起宿主體的應答，促進或抑制組織愈合。由于降解材料在體內(nèi)的降解產(chǎn)物會隨時間而變，產(chǎn)生的宿主體應答就會不同，進而會影響組織的愈合。而促進或抑制組織愈合的機制就成為新型醫(yī)用高分子材料設計和制備的理論基礎。殼聚糖是理想的骨組織修復材料之一，但至今還不清楚殼聚糖體內(nèi)不同降解過程對組織修復的影響機制，也就無法設計出性能優(yōu)良的殼聚糖基新材料。文章沒有羅列殼聚糖基生物材料在骨組織工程中應用所取得的進展，而是重點闡述了殼聚糖在骨組織工程中應用的復雜性和對組織修復的影響，探討了殼聚糖進一步用于骨組織工程所需要解決的問題。

Abstract:: Materials implanted in the body would inevitably lead to host response, promoting or inhibiting tissue healing. The degradation products of biodegradable materials in the body will change with time, resulting in different host responses and further affecting tissue healing. Therefore, the mechanism of promoting or inhibiting tissue healing becomes the theoretical basis for the design and preparation of novel biomedical polymer materials. Chitosan is one of the ideal medical polymer materials, but we still do not know the effect mechanism of chitosan degradation process on tissue repair in vivo. So it will not be able to design chitosanbased materials with excellent performance. This review does not lay out the progress of the chitosanbased biomaterials applied in bone tissue engineering, but focuses on the complexity of chitosan applications for bone tissue engineering, furthermore investigates the problems needed to be solved for chitosan used in bone tissue engineering.