[1]李若琳,張云龍,寇宏超,等.膠原/HA復(fù)合涂層多孔鈦的細(xì)胞響應(yīng)行為[J].中國材料進(jìn)展,2018,(11):041-45.[doi:10.7502/j.issn.1674-3962.2018.11.09]
LI Ruolin,ZHANG Yunlong,KOU Hongchao,et al.Cellular Response on Collagen/HA Composite Coating of Porous Titanium[J].MATERIALS CHINA,2018,(11):041-45.[doi:10.7502/j.issn.1674-3962.2018.11.09]
點擊復(fù)制
膠原/HA復(fù)合涂層多孔鈦的細(xì)胞響應(yīng)行為(
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中國材料進(jìn)展[ISSN:1674-3962/CN:61-1473/TG]
- 卷:
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- 期數(shù):
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2018年第11期
- 頁碼:
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041-45
- 欄目:
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研究報告
- 出版日期:
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2018-11-30
文章信息/Info
- Title:
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Cellular Response on Collagen/HA Composite Coating of Porous Titanium
- 作者:
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李若琳1; 張云龍1; 寇宏超2; 李仁興1; 盧雅琳1
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(1. 江蘇理工學(xué)院材料工程學(xué)院，江蘇 常州 213001)(2. 西北工業(yè)大學(xué) 凝固技術(shù)國家重點實驗室，陜西 西安 710072)
- Author(s):
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LI Ruolin1; ZHANG Yunlong1; KOU Hongchao2; LI Renxing1 ; LU Yalin1
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(1. School of Materials Engineering，Jiangsu University of Technology，Changzhou 213001，China) (2. State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xian 710072, China)
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- 關(guān)鍵詞:
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多孔鈦; 羥基磷灰石涂層; 膠原; 細(xì)胞響應(yīng)
- Keywords:
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porous titanium; hydroxyapatite coating; collagen; cellular response
- DOI:
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10.7502/j.issn.1674-3962.2018.11.09
- 文獻(xiàn)標(biāo)志碼:
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A
- 摘要:
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為提高醫(yī)用多孔鈦的表面活性及生物相容性，以纖維燒結(jié)多孔鈦為載體，采用堿熱處理+模擬體液等化學(xué)方法進(jìn)行羥基磷灰石(HA)沉積，隨后進(jìn)行水溶性膠原涂覆，制備具有三維貫通孔結(jié)構(gòu)的膠原/HA復(fù)合涂層多孔鈦。研究了膠原/HA復(fù)合涂層的表面形貌及化學(xué)成分，探討復(fù)合涂層的形成機(jī)理；進(jìn)行體外細(xì)胞毒性實驗并分析了多孔鈦表面細(xì)胞響應(yīng)行為。結(jié)果表明，膠原/HA復(fù)合涂層在鈦纖維表面均勻附著，膠原的填充連接可修復(fù)HA涂層表面的微裂紋，有利于小鼠前成骨細(xì)胞的黏附、增殖及分化，促進(jìn)細(xì)胞的孔內(nèi)跨纖維生長。膠原/HA復(fù)合涂層可以得到更好的細(xì)胞響應(yīng)，對于促進(jìn)早期骨與植入體的固定有很大的潛力。
- Abstract:
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In order to improve the surface activity and biocompatibility of the medical porous titanium, sintered fibrous porous titanium was used as a carrier, the hydroxyapatite (HA) was deposited by alkaline heat treatment and simulated body fluids, then the water soluble collagen was coated on the HA surface to form collagen/HA composite coated porous titanium with threedimensional penetrating pore structure. The surface morphology and chemical composition of collagen/HA composite coating were studied, the formation mechanism of collagen/HA composite coating was discussed. The cytotoxicity in vitro was tested and the cell response behavior on porous titanium surface was analyzed. The results show that the collagen/HA composite coating was uniformly adhered on the surface of the titanium fiber, the microcracks on the surface of HA coating can be repaired by collagen filling, which improves adhesion, proliferation, differentiation of mouse previous osteoblasts and the interfiber growth. HA/collagen composite coating shows an improved cellular response and an promotion of fixation between early bone and implant.
更新日期/Last Update:
2018-12-10