文章信息/Info

Title:

Research Progress of Bioglass in Tissue Regeneration

文章編號:

1674-3962(2020)02-0151-05

作者:

李倩1; 陳瑞果2; 謝巖黎1

（1. 河南工業(yè)大學(xué)糧油食品學(xué)院，河南 鄭州 450001）（2. 中國科學(xué)院合肥物質(zhì)科學(xué)研究院 強磁場中心，安徽 合肥 230031）

Author(s):

LI Qian1;  CHEN Ruiguo2;  XIE Yanli1

(1. School of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China) (2. High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China)

關(guān)鍵詞:

生物玻璃; 離子; 生物學(xué)效應(yīng); 組織修復(fù); 復(fù)合材料

Keywords:

bioglass;  ions;  biological effects;  tissue repair;  composite materials

分類號:

R318.08

DOI:

10.7502/j.issn.1674-3962.201902011

文獻標(biāo)志碼:

A

摘要:

生物玻璃最早被應(yīng)用于硬骨組織修復(fù)，近些年越來越多的研究證明其還可用于修復(fù)軟骨和軟組織，如皮膚、角膜、肺、神經(jīng)組織等。具有代表性的生物玻璃包括硅酸鹽生物玻璃和硼酸鹽生物玻璃，這類生物玻璃在體內(nèi)環(huán)境中能夠快速釋放大量的離子，發(fā)揮特殊的生物學(xué)效應(yīng)，如抑菌活性，細(xì)胞附著、繁殖和遷移、血管生成等。摻雜元素對生物玻璃的性能起到重要的作用，進而調(diào)控組織修復(fù)中的不同效果。并且，生物玻璃的結(jié)構(gòu)也對細(xì)胞的生長及組織修復(fù)有著重要的作用。由于生物玻璃韌性低、脆性高，常與金屬、多聚物等制備成復(fù)合材料應(yīng)用于組織修復(fù)。綜述了生物玻璃物理化學(xué)性質(zhì)與生物學(xué)活性的關(guān)系，同時介紹和探討了基于生物玻璃衍生出來的復(fù)合材料及其應(yīng)用，為開發(fā)新型的組織修復(fù)材料提供參考。

Abstract:

Bioglass was firstly invented to regenerate bone, in recent years it has also been applied in the regeneration of cartilage and soft tissues, such as skin, cornea, lung and nerve. The representative bioglass includes silicate bioglass and borate bioglass, they release abundant ions in physiological environment and induce specific biological responses, such as antibacterial effect, promoting cell adhesion, proliferation, migration and angiogenesis. Doping elements are crucial for the properties of bioglass, which perform different effects in tissue healing. What’s more, the structure of bioglass is also important for cell growth and tissue repair. Due to the adverse properties of bioglass, such as low toughness and high fragility, it is usually compounded with metals，polymers as composite materials to be applied in tissue repair. In this paper, the relationship between physical and chemical properties of bioglass and its bioactivity is reviewed, the recent application progress of composite materials derived from bioglass is introduced and discussed, which will provide reference for the advanced medical materials in the field of tissue regeneration.