文章信息/Info

Title:

Progress in Natural Polysaccharide-Based Injectable Hydrogels for Tissue Engineering

文章編號(hào):

1674-3962(2021)05-0374-10

作者:

張潤婧; 陳玉潔; 蔡超; 陳震; 劉河洲

（上海交通大學(xué)材料科學(xué)與工程學(xué)院 金屬基復(fù)合材料國家重點(diǎn)實(shí)驗(yàn)室，上海 200240）

Author(s):

ZHANG Runjing;  CHEN Yujie;  CAI Chao;  CHEN Zhen;  LIU Hezhou

(State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China)

關(guān)鍵詞:

水凝膠; 可注射性; 組織工程; 天然多糖; 功能化

Keywords:

hydrogels;  injectability;  tissue engineering;  natural polysaccharide;  functionality

分類號(hào):

O636.1

DOI:

10.7502/j.issn.1674-3962.201912004

文獻(xiàn)標(biāo)志碼:

A

摘要:

組織工程技術(shù)是幫助人類器官或組織進(jìn)行修復(fù)的重要手段。水凝膠材料具有與人體組織相似的三維多孔網(wǎng)狀結(jié)構(gòu)，是組織工程中的優(yōu)選材料。可注射水凝膠能夠以微創(chuàng)手段植入人體，可以填充不規(guī)則缺損、降低手術(shù)風(fēng)險(xiǎn)并提升操作便捷性。天然多糖基可注射水凝膠具備優(yōu)異的生物相容性及生物降解性，非常適合用作醫(yī)用植入材料。近年來，基于天然多糖材料的可注射水凝膠引發(fā)廣泛關(guān)注，研究者針對其制備方法及其在組織工程領(lǐng)域的應(yīng)用開展了大量工作并取得長足進(jìn)展。介紹了天然多糖基可注射水凝膠的幾類典型多糖聚合物原料，闡述了可注射水凝膠的設(shè)計(jì)機(jī)理，并總結(jié)了此類水凝膠在強(qiáng)度提升、生物打印兩大方向的功能化研究成果。在此基礎(chǔ)上，對天然多糖基可注射水凝膠的未來發(fā)展方向進(jìn)行了展望。

Abstract:

Tissue engineering technology is a vital method to develop biological substitutes that restore damaged tissues. The porous networks of hydrogels with resemblance to human tissues make them promising candidates for tissue engineering. Injectable hydrogels with ease of handling and complete filling of irregular defects can be implanted in bodies through minimally invasive surgical procedures, which reduces administration risks effectively. Natural polysaccharide-based injectable hydrogels are especially attractive as medical implanting biomaterials due to their excellent biocompatibility and biodegradability. In recent years, injectable hydrogels based on natural polysaccharide materials have been paid much attention. The fabrication methods and applications in tissue engineering of natural polysaccharide-based injectable hydrogels have been widely studied. This review summarized typical natural polysaccharide materials and crosslinking mechanisms of natural polysaccharide-based injectable hydrogels. Meanwhile, the progress of functionality in high-strength and 3D bioprinting was reviewed. Finally, future challenges and perspectives of natural polysaccharide-based injectable hydrogels in tissue engineering were proposed．