文章信息/Info

Title:

Development of Hydrotalcite Nanomaterials in Biomedical Application

文章編號(hào):

1674-3962(2022)09-0749-09

作者:

吳捷; 王莉; 唐薇; 程亮

（蘇州大學(xué)功能納米與軟物質(zhì)研究院 蘇州納米科技協(xié)同創(chuàng)新中心, 江蘇 蘇州 215123）

Author(s):

WU Jie;  WANG Li;  TANG Wei;  CHENG Liang

(Suzhou Nanotechnology Collaborative Innovation Center, Institute of Functional Nanotechnology and Soft Matter, Soochow University, Suzhou 215123, China)

關(guān)鍵詞:

水滑石; 生物納米材料; 腫瘤治療; 抗菌; 骨修復(fù)

Keywords:

hydrotalcite;  biological nanomaterials;  tumor therapy;  antibacterial;  bone repair

分類(lèi)號(hào):

TB33; TB383.1; R318.08

DOI:

10.7502/j.issn.1674-3962.202208009

文獻(xiàn)標(biāo)志碼:

A

摘要:

在公眾健康意識(shí)不斷提高的背景下，二維納米材料因其獨(dú)特的各向異性和大的比表面積，已在各種生物醫(yī)學(xué)應(yīng)用中得到了廣泛的探索。水滑石納米材料即層狀雙氫氧化物（layered double hydroxides，LDHs）具有多種物理化學(xué)優(yōu)勢(shì)，包括優(yōu)異的生物相容性、pH敏感的生物降解性、高度可調(diào)的化學(xué)成分和結(jié)構(gòu)，并且易于與其他材料形成復(fù)合材料，在生物醫(yī)學(xué)應(yīng)用中顯示出巨大的前景。總結(jié)了基于LDHs的納米材料在生物醫(yī)學(xué)應(yīng)用方面的最新進(jìn)展。首先討論了LDHs基納米材料的定義及其制備方法；然后系統(tǒng)地描述了LDHs在生物醫(yī)學(xué)應(yīng)用中的巨大潛力，重點(diǎn)從癌癥治療、抗菌、骨修復(fù)和生物傳感等生物領(lǐng)域進(jìn)行了全面的闡述；最后，在當(dāng)前技術(shù)水平的基礎(chǔ)上，對(duì)這個(gè)快速興起的領(lǐng)域面臨的挑戰(zhàn)和未來(lái)發(fā)展戰(zhàn)略做出了展望，期望能推動(dòng)其讓患者受益的生物醫(yī)學(xué)應(yīng)用。

Abstract:

Against the backdrop of increasing public health awareness, two-dimensional nanomaterials have been extensively explored in various biomedical applications due to their unique anisotropy and large specific surface area properties. Layered double hydroxides (LDHs), also named hydrotalcite nanomaterials, have multiple physicochemical advantages, including excellent biocompatibility, pH-sensitive biodegradability, highly tunable chemical composition and structure, and easy to form composites with other materials, showing great promise in biomedical applications. In this review, we summarize recent advances in LDHs-based nanomaterials for biomedical applications. First, the material definition of LDHs-based nanomaterials and their preparation methods are discussed. We then systematically describe the great potential of LDHs for biomedical applications, focusing on comprehensive elaboration in biological fields such as cancer therapy, antibacterial, tissue engineering repair, and biosensing. Finally, building on the current state of the art, we provide insights into the challenges and future development strategies of this rapidly emerging field, which we expect to advance into biomedical applications that benefit patients.