文章信息/Info

Title:

Advances in the Design and Recognition Mechanism of Fluorescent Probes for Copper Ions

文章編號(hào):

1674-3962(2024)06-0533-10

作者:

裴楊瀾; 胡堃; 王峻東; 李路海; 危巖

1.北京印刷學(xué)院印刷與包裝工程學(xué)院，北京 102600 2.中南大學(xué)化學(xué)化工學(xué)院，湖南 長沙 410083 3.清華大學(xué)化學(xué)系，北京 100084

Author(s):

PEI Yanglan;  HU Kun;  WANG Jundong;  LI Luhai;  WEI Yen

1.School of Printing and Packaging Engineering, Beijing Institute of Graphic Communication, Beijing 102600, China 2. College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China 3. Department of Chemistry, Tsinghua University, Beijing 100084, China

關(guān)鍵詞:

熒光探針; 銅離子; 識(shí)別機(jī)制; 生物成像

Keywords:

fluorescent probe;  copper ion;  identification mechanism;  bioimaging

分類號(hào):

O621;R318.08

DOI:

10.7502/j.issn.1674-3962.202309032

文獻(xiàn)標(biāo)志碼:

A

摘要:

銅（Cu）是人體內(nèi)僅次于鐵（Fe）和鋅（Zn）的第三大豐富元素，也是生命不可或缺的組成部分，但過量攝入Cu會(huì)損傷紅細(xì)胞和神經(jīng)系統(tǒng)。因此，銅離子（Cu2+）的檢測(cè)在生物醫(yī)學(xué)和環(huán)境領(lǐng)域越來越受到重視。在眾多Cu2+的檢測(cè)方法中，熒光探針具有操作方便、靈敏度高且適用于環(huán)境和細(xì)胞檢測(cè)等優(yōu)點(diǎn)，可以對(duì)細(xì)胞及生物體中的Cu2+進(jìn)行動(dòng)態(tài)標(biāo)記，實(shí)現(xiàn)實(shí)時(shí)生物成像，具有廣闊的研發(fā)前景。歸納總結(jié)了近5年用于Cu2+檢測(cè)的熒光探針的研究進(jìn)展，根據(jù)對(duì)Cu2+識(shí)別機(jī)制的不同，對(duì)此類熒光探針進(jìn)行分類，闡述了Cu2+探針的分子結(jié)構(gòu)和使用性能，并對(duì)進(jìn)一步優(yōu)化Cu2+熒光探針的發(fā)光性質(zhì)和檢測(cè)限提出了展望。

Abstract:

While copper is a vital element for life and the third most abundant element in the body after iron and zinc, too much copper can harm the neurological system and red blood cells. As a result, the detection of copper ions has received increasing interest in the biomedical and environmental fields. Fluorescence probes, one of the techniques for detecting copper ions, have the advantages of being simple to use, highly sensitive, and applicable to both environmental and cellular detection. They can also be used to realize real�瞭ime bioimaging by dynamically labeling copper ions in cells and organisms, and offer a wealth of opportunities for further research and development. We describe the molecular structure and performance of the copper ion pairs of probes, classify such fluorescent probes according to the various recognition mechanisms of copper ions, summarize the research progress of fluorescent probes for copper ion detection in recent years, and suggest further optimization of the luminescence properties and detection limits of the copper ion fluorescent probes.