文章信息/Info

Title:

Additive Manufacturing of Biodegradable Magnesium Alloy Customized Bone Implants

文章編號(hào):

1674-3962(2024)11-0972-09

作者:

徐皓璟; 尹浜兆; 彭勃; 劉金戈; 田耘; 鄭玉峰; 溫鵬

1. 清華大學(xué) 清潔高效透平動(dòng)力裝備全國重點(diǎn)實(shí)驗(yàn)室，北京 100084 2. 清華大學(xué)機(jī)械工程系，北京 100084 3. 清華大學(xué)航天航空學(xué)院，北京 100084 4.北京大學(xué)第三醫(yī)院 骨科，北京 100191 5.北京大學(xué)材料科學(xué)與工程學(xué)院，北京 100871

Author(s):

XU Haojing;  YIN Bangzhao;  PENG Bo;  LIU Jinge;  TIAN Yun;  ZHENG Yufeng;  WEN Peng

1. State Key Laboratory of Clean and Efficient Turbomachinery Power Equipment, Beijing, 100084, China 2. Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China 3. School of Aerospace Engineering, Tsinghua University, Beijing 10084, China et al.

關(guān)鍵詞:

鎂合金骨植入物; 增材制造; 成分調(diào)控; 結(jié)構(gòu)設(shè)計(jì); 后處理

Keywords:

magnesium alloy bone implant;  additive manufacturing;  component control;  structural design;  postprocessing

分類號(hào):

R318.08；TG146.22

DOI:

10.7502/j.issn.1674-3962.202404037

文獻(xiàn)標(biāo)志碼:

A

摘要:

隨著老年人口數(shù)量的增加，骨科疾病的發(fā)生率持續(xù)上升，社會(huì)對(duì)骨植入物的需求顯著提高。傳統(tǒng)骨植入物不可降解的特性限制了骨缺損的治療效果。鎂作為一種生物相容性優(yōu)異、力學(xué)性能良好的可降解金屬，被公認(rèn)為一種極具前途的新型骨植入物材料。通過增材制造技術(shù)成形定制化鎂合金骨植入物，一方面，外形精確匹配患者的骨缺損外形，另一方面，內(nèi)部的多孔結(jié)構(gòu)利于新骨長(zhǎng)入。然而現(xiàn)階段增材制造鎂合金骨植入物存在降解周期與骨愈合周期不匹配的問題，限制了其在骨植入物領(lǐng)域的推廣應(yīng)用。介紹了鎂合金骨植入物的增材制造工藝以及面臨的挑戰(zhàn)，并從成分調(diào)控、結(jié)構(gòu)設(shè)計(jì)、后處理3個(gè)方面介紹了調(diào)控鎂合金植入物降解行為、力學(xué)性能和生物性能的策略。最后提出了鎂合金骨植入物的潛在研究方向和未來展望。

Abstract:

With the increase in the elderly population, the incidence of orthopedic diseases continues to rise, and there is a significantly increasing demand for bone implants. Traditional undegradable bone implants pose great limitations in bone defects treatment. Magnesium, as a degradable metal with excellent biocompatibility and mechanical properties, is recognized as a promising bone implant material. Customized magnesium alloy bone implants fabricated by additive manufacturing can accurately match the patient�餾 bone defect shape,and the internal porous structure facilitates new bone growth. However,the current additive manufacturing of magnesium alloy bone implants suffers from the mismatch between the degradation cycle and the bone healing cycle,constraining its application in the field of bone implants. This paper elucidates the additive manufacturing processes for magnesium alloy bone implants and the challenges faced, and outlines strategies for modulating their degradation behavior, mechanical characteristics and biological properties through three primary avenues: composition, structural design, and postprocessing. Finally, the potential research directions and future prospects of magnesium alloy bone implants are proposed.